MOCA's permanent collection reflects significant artistic developments in contemporary art by emerging and established artists from the U.S. and abroad and has made the collection and exhibition of installation art, video and film a special focus of its permanent collection. In 2007, MOCA and Tate, Great Britain, received a landmark donation from Rosa and Carlos de la Cruz of No Ghost Just A Shell, a multi-media collaboration of 17 international artists originated by Pierre Huyghe and Philipe Parreno, and Zero Hero, a monumental multi-media installation by John Bock.
In December 2005, the Museum of Contemporary Art opened a satellite exhibition and art warehouse space, MOCA at Goldman Warehouse, in the Wynwood Arts and Entertainment District of Miami (404 NW 26th Street, Miami). This space was donated to MOCA through the year 2009 by Tony Goldman and Joey Goldman and is used to present exhibitions and projects by emerging artists and works from the permanent collection.
John Baldessari, Dan Flavin, Dennis Oppenheim, Alex Katz, Louise Nevelson, Gabriel Orozco, Julian Schnabel, Zoe Leonard, Uta Barth, Teresita Fernandez, Jorge Pardo, Garry Simmons, Mathew Ritchie, Raymond Pettibon, Yoko Ono, Christian Marclay, Nam June Paik, Inka Essenhigh, Trenton Doyle Hancock, and Jose Bedia are among the artists whose works are included in the collection.